You can read about the features here:
SAP PowerBuilder 12.6 – SAP Help Portal Page
Unfortunately, the documents contain links to the Sybase.com web site for more information, which is currently redirected to the SAP.com site with no specific page selected.
.NET 4.0 and 4.5 are supported as well as windows 8.0 and 8.1. I did not see ORA12 or MSS12 in the documents.
Randy