Dear Uma,
1) First create two house bank of your choice using FBZP or FI12.
2) If you are doing check payment for both vendors with two different banks. Then you have to create only one payment method in your company code and map this against with your House Banks and payment methods (FBZP- Bank Determination). Check the below screen shot.
3) Similarly if you are doing payment with two different payment methods like C & P then the same way you have map those against your house banks and payment methods and bank accounts. Check the above screen shot.
4) Assign the Payment methods and house bank details in vendor master record.
5) give the both payment methods (If there are 2) in F110 under parameters tab.
6)you can cross verify the details while running the F110 from payment proposal.
hope this is helpful. Thanks.
Regards,
Inthiyaz